9028-76-6胆固醇氧化酶来源于微生物

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商品编号：C139686

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商品名称：9028-76-6胆固醇氧化酶来源于微生物
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单位：件
上架时间：2017-11-01 20:36:58

名称: 胆固醇氧化酶来源于微生物英文名称: Cholesterol Oxidase from microorganism>10U/mg产品编号 C139686
CAS号: 9028-76-6分子式分子量
Beilstein号 EC号 232-842-1MDL号 MFCD00130783PubChem编号

属性

存贮条件	储存温度 -20°C

描述

产品介绍	Cholesterol oxidase has been used in a study to improve treatment of oxysterol-mediated cytotoxicity. Cholesterol oxidase has also been used in a study that determined that cholesterol depletion impairs coupling between channel opening and vesicle release by allowing voltage-gated calcium channels to move further from release sites. Cholesterol oxidase has been used in a study to improve treatment of oxysterol-mediated cytotoxicity. Cholesterol oxidase has also been used in a study that evaluated the effects of cholesterol depletion. This study reported that cholesterol depletion impairs the coupling between channel opening and vesicle release. Additionally, cholesterol oxidase is used to determine serum cholesterol levels. The enzyme also finds application in the microanalysis of steroids in food samples. It has also been used for distinguishing 3-ketosteroids from 3β-hydroxysteroids. Transgenic plants expressing cholesterol oxidase have been investigated in the fight against the cotton boll weevil. CHOD has also been used as a molecular probe to elucidate cellular membrane structures.
别名	;Oxidase cholesterol;
生化机理	胆固醇氧化酶及胆固醇脂酶一起用于血脂类项目如高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）以及总胆固醇（CHO）等。
应用	Cholesterol oxidase (CHOD) is a monomeric flavoprotein containing FAD that catalyzes the first step in cholesterol catabolism. This bifunctional enzyme oxidizes cholesterol to cholest-5-en-3-one in an FAD-requiring step. The pH optimum of the enzyme is 7.0 to 7.5 and temperature optimum is 50 °C. The pH stability is 5.7-7.8. Hg2+, Ag+, and ionic detergents inhibit the enzyme activity. Molecular mass of the enzyme is 62 kDa. Pathogenic bacteria require CHOD to infect a host′s macrophage