9004-07-3α-糜蛋白酶来源于牛胰腺(TLCK处理)

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商品编号：C129079

库存现货：9

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商品名称：9004-07-3α-糜蛋白酶来源于牛胰腺(TLCK处理)
商品毛重：0.00
单位：件
上架时间：2017-11-01 18:30:22

名称: α-糜蛋白酶来源于牛胰腺(TLCK处理)英文名称: α-Chymotrypsin from bovine pancreas(TLCK Treated)≥45 units/mg protein产品编号 C129079
CAS号: 9004-07-3分子式分子量
Beilstein号 EC号 232-671-2MDL号 MFCD00130481PubChem编号

标识符号	GHS07, GHS08
信号词	Danger
风险声明 (欧洲)	R36/37/38;R42
安全声明（欧洲）	S22;S24;S26;S36/37
警示性声明	P261,P305+P351+P338,P342+P311
危害码（欧洲）	Xn
危害声明	H315,H319,H334,H335
个人防护设备	dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RTECS	GC3050000
WGK德国	1

属性

敏感性	易潮湿
存贮条件	储存温度2-8℃

描述

产品介绍	Chymotrypsin preferentially catalyzes the hydrolysis of peptide bonds involving L-isomers of tyrosine, phenylalanine and tryptophan. It also readily acts upon amides and esters of susceptible amino acids. Chymotrypsin catalyzes the hydrolysis of bonds of leucyl, methionyl, asparaginyl and glutamyl residues.
别名	α-胰凝乳蛋白酶;
生化机理	一种丝氨酸蛋白酶，能将与芳香烃或其他大型疏水性侧链（Tyr、Trp、Phe、Met、Leu）结合的肽从键的羧基端水解。 α-Chymotrypsin is a serine peptidase and has 241 amino acid residues contained in three polypeptide chains (A chain-13 residues, B chain-131 residues, and C chain-97 residues) linked by disulfide bridges. Molecular weight of this enzyme is found to be 25 kDa. Its pI is 8.75. It selectively hydrolyzes peptide bonds on the C-terminal side of tyrosine, phenylalanine, tryptophan, and leucine. Ca2+ activates and stabilizes the enzyme. The enzyme is inhibited by diisopropyl fluorophosphate (DFP), phenylmethanesulfonyl fluoride (PMSF), N-p-tosyl-L-phenylalanine chloromethyl ketone (TPCK), chymostatin, aprotinin, α1-antitrypsin, and α2-macroglobulin, 10 mM Cu2+ and Hg2+.
备注	Three times crystallized and treated with 1-chloro-3-tosylamido-7-amino-2-heptanone (TLCK) to inhibit trypsin activity [Shaw, et al., Biochemistry, 4, 2219 (1965)]. Dialyzed against 1 mM HCl to remove autolysis products and low molecular weight contaminants. Supplied as a dialyzed, lyophilized powder.