553-21-9木香烃内酯

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商品编号：C115678

库存现货：9

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商品名称：553-21-9木香烃内酯
商品毛重：0.00
单位：件
上架时间：2017-11-01 18:26:44

名称: 木香烃内酯英文名称: Costundide分析标准品,>98%产品编号 C115678
CAS号: 553-21-9分子式 C₁₅H₂₀O₂分子量232.32
Beilstein号 EC号 MDL号 MFCD00210262PubChem编号

属性

密度	1.0300
溶解性	Soluble in ethanol (50 mM), DMSO (47 mg/ml at 25 °C), and water (
存贮条件	储存温度-20°C

描述

产品介绍	Costunolide is a sesquiterpene lactone isolated from Magnolia sieboldii. The compound is described to act as an antioxidant, anti-mycobacterial, anti-inflammatory, and anti-viral, with cytotoxic activity. Additionally, Costunolide is reported to inhibit the activity of TERT (telomerase). Studies indicate that Costunolide activates JNK downstream of ROS in leukemia cells, and upstream of Bcl-2. The compound has also been suggested to act as an inhibitor of NOS (nitric oxide synthase) and the VEGFR KDR/Flk-1 signaling pathway
别名	;(3aS,6E,10E,11aR)-6,10-Dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[d]furan-2-one
生化机理	Description: IC50 Value: 6.2 - 9.8 ?g/mL(sarcoma cells viability)[3] Costunolide, a sesquiterpene lactone, exhibits anti-inflammatory and anti-oxidant properties and mediates apoptosis. in vitro: Costunolide significantly inhibited RANKL-induced BMM differentiation into osteoclasts in a dose-dependent manner without affecting cytotoxicity. Costunolide did not regulate the early signaling pathways of RANKL, including the mitogen-activated protein kinase and NF-κB pathways. However, costunolide suppressed nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) expression via inhibition of c-Fos transcriptional activity without affecting RANKL-induced c-Fos expression. The inhibitory effects ofcostunolide were rescued by overexpression of constitutively active (CA)-NFATc1 [1]. Exposure of T24 cells to costunolide was also associated with increased expression of Bax, down-regulation of Bcl-2, survivin and significant activation of caspase-3, and it
应用	A sequiterpene lactone that inhibits telomerase