848695-25-0BIIB021

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商品编号：B127837

库存现货：9

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商品名称：848695-25-0BIIB021
商品毛重：0.00
单位：件
上架时间：2017-10-31 22:54:36

名称: BIIB021英文名称: BIIB021≥98%产品编号 B127837
CAS号: 848695-25-0分子式 C₁₄H₁₅ClN₆O分子量318.77

属性

溶解性	DMSO ≥60mg/mL Water
存贮条件	储存温度-20°C

描述

产品介绍	BIIB021(CNF2024)是口服活性的HSP90抑制剂，Ki和EC50分别为1.7 nM和38 nM。
别名	BIIB-021; BIIB 021; 6-氯-9-((4-甲氧基-3,5-二甲基-2-吡啶基)甲基)-9H-嘌呤-2-胺;;CNF2024; ;CNF 2024;CNF-2024;6-chloro-9-((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)-9h-purin-2-amine;1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one
生化机理	Oral administration of BIIB021 leads to tumor growth inhibition in many tumor xenograft models including N87, BT474, CWR22, U87, SKOV3 and Panc-1. BIIB021 effectively inhibits growth of L540cy tumor at a dose of 120 mg/kg. BIIB021 significantly enhances antitumor growth effect of radiation in JHU12 xenograft.
备注	BIIB021 is an orally available, fully synthetic small-molecule inhibitor of HSP90 with K_i and EC50 of 1.7 nM and 38 nM, respectively.
应用	A selective large conductance calcium activated potassium channel activator