71675-85-9Amisulpride

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商品编号：A129432

库存现货：9

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商品名称：71675-85-9Amisulpride
商品毛重：0.00
单位：件
上架时间：2017-10-31 22:41:08

名称: Amisulpride英文名称: Amisulpride≥98%产品编号 A129432
CAS号: 71675-85-9分子式 C₁₇H₂₇N₃O₄S分子量369.48
Beilstein号 EC号 275-831-7MDL号 MFCD00866691PubChem编号 24890689

标识符号	GHS07
信号词	Warning
危害声明	H302
个人防护设备	dust mask type N95 (US), Eyeshields, Gloves
RTECS	CV2308701
WGK德国	3

属性

敏感性	对热、湿度和光线敏感
溶解性	Soluble in water (partly), dichloromethane, chloroform, DMSO (50 mM), 1eq. HCl (25 mM), methanol, and ethanol (74 mg/ml at 25 °C).
存贮条件	储存温度 2-8°C

描述

产品介绍	Amisulpride是一种非典型的抗精神病药物，用于治疗精神病的精神分裂症和双相情感障碍的躁狂发作。
别名	阿米舒必利; 4-氨基-N-[(1-乙基-2-吡咯烷基)甲基]-5-(乙基磺酰基)-2-甲氧基苯甲酰胺;4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-ethylsulfonyl-2-methoxybenzamide;DAN-2163;Deniban;DAN 2163; DAN2163; Solian
生化机理	Amisulpride is a selective, potent D2DR and D3DR inhibitor. (Ki values are 2.8 and 3.2 nM respectively for human D2DR and D3DR and > 1000 nM for human D1DR, D4DR and D5DR.) Amisulpride exhibits selectivity for presynaptic dopamine autoreceptors at low doses and blocks postsynaptic D2DR/D3DR at higher doses. Amisulpride interacts with limbic D2-like receptors . Amisulpride is an atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects and a profile distinct from that of haloperidol and remoxipride.
备注	Amisulpride is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder.
应用	A selective D2DR and D3DR inhibitor.