722544-51-6Barasertib (AZD1152-HQPA)

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商品编号：A127799

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商品名称：722544-51-6Barasertib (AZD1152-HQPA)
商品毛重：0.00
单位：件
上架时间：2017-10-31 22:40:53

名称: Barasertib (AZD1152-HQPA)英文名称: Barasertib (AZD1152-HQPA)≥97%产品编号 A127799
CAS号: 722544-51-6分子式 C₂₆H₃₀FN₇O₃分子量507.56
MDL号 MFCD10687152

属性

折光率	1.68
沸点	796.7° C at 760 mmHg
溶解性	DMSO ≥100mg/mL Water ≥100mg/mL Ethanol ≥2.8mg/mL
存贮条件	储存温度-20°C

描述

产品介绍	AZD1152-HQPA是AZD-1152的活性代谢物，AZD1152-HQPA (Barasertib)是Aurora B 高选择性抑制剂，IC50为0.37 nM，比对Aurora A的抑制性高100倍。
别名	AZD1152; AZD 1152; 5-((7-(3-(乙基(2-羟基乙基)氨基)丙氧基)-4-喹唑啉)氨基)-N-(3-氟苯基)-1H-吡唑-3-乙酰胺;;Barasertib;5-((7-(3-(ethyl(2-hydroxyethyl)amino)propoxy)-4-quinazolinyl)amino)-n-(3-fluorophenyl)-1h-pyrazole-3-acetamide；3-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-5-acetamide
生化机理	AZD1152-HQPA is the active metabolite of AZD-1152, a potent selective Aurora Kinase B inhibitor. AZD1152 is 50-fold selective for Aurora kinase B over Aurora kinase C and over 1000-fold selective for Aurora kinase B over Aurora Kinase A. (IC50s: aurora-A, 1,369 nmol/L; aurora-B, 0.36 nmol/L; aurora-C, 17.0 nmol/L). It is converted in plasma to the active form AZD1152-HQPA, which has been shown to have antineoplastic activity in a variety of animal models and human cancer cell lines.
备注	AZD1152-HQPA (Barasertib) is a highly selective Aurora B inhibitor with IC50 of 0.37 nM, ~100 fold more selective for Aurora B over Aurora A.
应用	A highly selective ARK-2 inhibitor