1009298-59-2AZD2014

￥0.00 ￥~~0.00~~

商品编号：A127600

库存现货：9

顾客评分：

(已有0人评价)

购买数量：

+ -

添加收藏

热卖商品

商品名称：1009298-59-2AZD2014
商品毛重：0.00
单位：件
上架时间：2017-10-31 22:40:51

名称: AZD2014英文名称: AZD2014≥98%产品编号 A127600
CAS号: 1009298-59-2分子式 C₂₅H₃₀N₆O₃分子量462.54
Beilstein号 EC号 MDL号 PubChem编号

属性

折光率	1.61
密度	1.2000
溶解性	DMSO 38 mg/mL Water Ethanol
存贮条件	储存温度-20°C

描述

产品介绍	AZD2014是高效mTOR抑制剂，IC50为2.8 nM，对PI3K各亚型(α/β/γ/δ)的抑制性较弱。
别名	AZD 2014; AZD-2014 3-(2,4-双((3S)-3-甲基吗啉-4-基)吡啶并(5,6-e)嘧啶-7-基)-N-甲基苯甲酰胺;;AZD 2014; AZD-2014;3-(2,4-bis((3s)-3-methylmorpholin-4-yl)pyrido(5,6-e)pyrimidin-7-yl)-n-methylbenzamide;3-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-N-methylbenzamide
生化机理	AZD2014 is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor AZD2014 inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR, a serine/threonine kinase that is upregulated in a variety of tumors, plays an important role downstream in the PI3K/Akt/mTOR signaling pathway.
备注	AZD2014 is a novel mTOR inhibitor with IC50 of 2.8 nM; highly selective against multiple PI3K isoforms (α/β/γ/δ). Phase 2.
应用	A selective inhibitor of mTOR kinase