90141-22-3AT-101

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商品编号：A127496

库存现货：9

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商品名称：90141-22-3AT-101
商品毛重：0.00
单位：件
上架时间：2017-10-31 22:40:50

名称: AT-101英文名称: AT-101产品编号 A127496
CAS号: 90141-22-3分子式 C₃₀H₃₀O₈分子量518.55

属性

溶解性	DMSO >80 mg/ml Ethanol >80 mg/ml
存贮条件	储存温度-20°C

描述

生化机理	AT-101 is orally bioavailable solvate of R-(-)-enantiomer of gossypol with potential antineoplastic activity. As a BH3 mimetic, AT-101 binds to the hydrophobic surface binding groove BH3 of the anti-apoptotic proteins Bcl-2 and Bcl-xL, blocking their heterodimerization with pro-apoptotic members of the Bcl-2 family of proteins such as Bad, Bid, and Bim; this may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. AT-101 induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. AT-101 delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo.