869357-68-6AZD8330

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商品编号：A127453

库存现货：9

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商品名称：869357-68-6AZD8330
商品毛重：0.00
单位：件
上架时间：2017-10-31 22:40:50

名称: AZD8330英文名称: AZD8330≥98%产品编号 A127453
CAS号: 869357-68-6分子式 C₁₆H₁₇FIN₃O₄分子量461.23

属性

折光率	1.66
密度	1.7300
溶解性	DMSO 92 mg/mL Water Ethanol 92 mg/mL
存贮条件	储存温度-20°C

描述

产品介绍	AZD8330(ARRY-424704; ARRY-704)是非ATP竞争性MEK 1/2抑制剂，IC50为7 nM。
别名	ARRY-424704; ARRY424704;ARRY704; AZD8330;2-(2-fluoro-4-iodophenylamino)-n-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide; AZD-8330; ARRY-704;2-(2-氟-4-碘苯氨基)-N-(2-羟基乙氧基)-1,5-二甲基-6-氧代-1,6-二氢吡啶-3-甲酰胺;
生化机理	AZD8330 potently and strongly inhibits MEK 1/2. AZD8330 has no inhibitory activity against over 200 other kinases including at concentrations up to 10 μM. AZD8330 demonstrates sub-nanomolar potency in mechanistic (pERK) and low to sub-nanomolar potency in functional (proliferation) assays in MEK 1/2 inhibitor sensitive cell lines.
备注	AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.
应用	An antineoplastic selective MEK inhibitor