794458-56-3360A

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商品编号：A127374

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商品名称：794458-56-3360A
商品毛重：0.00
单位：件
上架时间：2017-10-31 22:40:49

名称: 360A英文名称: 360A98%产品编号 A127374
CAS号: 794458-56-3分子式 C₂₇H₂₃N₅O₂分子量449.5

属性

溶解性	25°C: DMSO
存贮条件	储存温度-20°C

描述

产品介绍	360A是G-四联体结构高亲和性抑制剂。
别名	360 A；3,3'-[2,6-吡啶二基二(羰基亚氨基)]二[1-甲基喹啉鎓];360 A；3,3'-[2,6-Pyridinediylbis(carbonylimino)]bis[1-methylquinolinium]
生化机理	Description: IC50 Value: N/A 360A is a 2,6-pyridine-dicarboxamide derivative displaying strong affinity and selectivity for G-quadruplex structures and selective telomerase inhibition in vitro assays. 360A is a G-quadruplex ligand, which can influence the consequence of G-quadruplex formation and/or stabilization. in vitro: We found a S-phase accumulation in ATM-proficient, but not in ATM-deficient EBV-lymphocytes treated with 360A before induction of cell death. However, ATM status did not modify cell cycle distribution in 360A-treated SV40-fibroblasts and HeLa cells compared to DMSO treated controls [1]. DNA-PKcs-dependent NHEJ was responsible for sister telomere fusions as a direct consequence of G-quadruplex formation and/or stabilization induced by 360A on parental telomere G strands. NHEJ and HR activation at telomeres altered mitotic progression in treated cells [2]. This compound was shown to display a potent affinity and selectivity for telomeri