156053-89-3Alvimopan

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商品编号：A124975

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商品名称：156053-89-3Alvimopan
商品毛重：0.00
单位：件
上架时间：2017-10-31 22:40:34

名称: Alvimopan英文名称: Alvimopan≥98%产品编号 A124975
CAS号: 156053-89-3分子式 C₂₅H₃₂N₂O₄分子量424.53
Beilstein号 EC号 MDL号 PubChem编号

属性

旋光率	+46 to +52°, c = 1.0 in DMSO
溶解性	DMSO
存贮条件	储存温度2-8℃

描述

产品介绍	Alvimopan is a gastroprokinetic, peripheral-μ-opioid receptor antagonist.
别名	爱维莫潘; 2-([(2S)-2-([(3R,4R)-4-(3-羟基苯基)-3,4-二甲基哌啶-1-基]甲基)-3-苯基丙酰]氨基)乙酸;ADL 8-2698; Entereg; LY 246736;2-([(2S)-2-([(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl)-3-phenylpropanoyl]amino)acetic acid
生化机理	Alvimopan(ADL 8-2698; Entereg; LY 246736) is a selective and competitive antagonist at mu-opioid receptors, found in myenteric and submucosal neurons and the immune cells of the lamina propria in the human gut. Upon administration, Alvimopan(ADL 8-2698; Entereg; LY 246736) binds to mu-opioid receptors in the gut, thereby reversing opiod-related disturbances in gut motility. Alvimopan is approximately three to nine times more potent than naloxone.A synthetic trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity.
应用	A gastroprokinetic, peripheral μ-opioid receptor antagonist.